3-nitro-4H-pyrazolo[1,5-a]pyrimidin-5-one
3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one
CAS: 1919868-75-9
Molecular Formula: C6H4N4O3
3-nitro-4H-pyrazolo[1,5-a]pyrimidin-5-one - Names and Identifiers
3-nitro-4H-pyrazolo[1,5-a]pyrimidin-5-one - Physico-chemical Properties
| Molecular Formula | C6H4N4O3 |
| Molar Mass | 180.12096 |
3-nitro-4H-pyrazolo[1,5-a]pyrimidin-5-one - Upstream Downstream Industry
| Downstream Products | (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine LOXO-101 (sulfate) |
3-nitro-4H-pyrazolo[1,5-a]pyrimidin-5-one - Introduction
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one is an organic compound with the chemical formula C6H3N5O3 and a molecular weight of 193.12g/mol.
Nature:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one is a yellow to orange solid. It has high thermal and chemical stability, and can be dissolved in a variety of organic solvents.
Use:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one has important applications in the field of chemistry. It is an intermediate of many drugs and can be used to synthesize various nitrogen-containing heterocyclic compounds. In addition, it is also used as a synthetic raw material for dyes and pigments.
Method:
The preparation of 3-nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one is generally carried out by chemical synthetic methods. One common method is to react 2-pyrazolone with nitric acid to produce 3-nitropyrazolone. Then, 3-nitropyrazolone was reacted with 2,4-diaminopyrazine by Alkaline condensation to give 3-nitropyrazolo [1,5-a] pyrimidine-5 (4H)-Keto.
Safety Information:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one has a stimulating effect on the skin, eyes and respiratory system, therefore, it is necessary to pay attention to protective measures when using. Appropriate protective gloves, goggles and protective mask shall be worn during operation. In addition, it is also a combustible substance and needs to be stored in a cool, dry and ventilated place, away from fire and heat sources. Local waste disposal regulations should be observed when disposing of waste.
Nature:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one is a yellow to orange solid. It has high thermal and chemical stability, and can be dissolved in a variety of organic solvents.
Use:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one has important applications in the field of chemistry. It is an intermediate of many drugs and can be used to synthesize various nitrogen-containing heterocyclic compounds. In addition, it is also used as a synthetic raw material for dyes and pigments.
Method:
The preparation of 3-nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one is generally carried out by chemical synthetic methods. One common method is to react 2-pyrazolone with nitric acid to produce 3-nitropyrazolone. Then, 3-nitropyrazolone was reacted with 2,4-diaminopyrazine by Alkaline condensation to give 3-nitropyrazolo [1,5-a] pyrimidine-5 (4H)-Keto.
Safety Information:
3-Nitropyrazolo [1,5-a] pyrimidin-5 (4H)-one has a stimulating effect on the skin, eyes and respiratory system, therefore, it is necessary to pay attention to protective measures when using. Appropriate protective gloves, goggles and protective mask shall be worn during operation. In addition, it is also a combustible substance and needs to be stored in a cool, dry and ventilated place, away from fire and heat sources. Local waste disposal regulations should be observed when disposing of waste.
Last Update：2024-04-09 20:52:54
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